Longitudinal assessment of associated factors with mortality in paraquat poisoning

In Colombia, paraquat poisoning (PQ) is one of the main causes self-inflicted pesticide poisoning. There not antidotal treatment against its toxicity, influencing an uncertain prognosis and changeful survival. Objective: To describe patients with PQ treated in a high-level hospital to evaluate association mortality clinical laboratory test variables, considering variation over time. Methods: Retrospective study between 2011 2018 at Hospital San Vicente Fundación (Medellín, Colombia). Included cases diagnosed poisoning, any age sex. Diagnoses concomitant intake other toxins, underlying lung disease, trauma were excluded. Sociodemographic characteristics described, effect on time analyzed, search for prognostic research candidates. Results: Cohort 67 patients, mostly single men, under 30 years age, located rural area was recruited. A 37.3% (95% CI 36.9 37.7%) found, median death 117 h (IQR 62h-238h). The instantaneous risk dying male sex 1.93; 95% 1.44 10.26; p = 0.007. Laboratory changes time: AST (HR 1.009; CI; 1.007-1.012; p≤0.001), ALT 1.008; 1.006-1.01; total bilirubin 1.23; 1,173-1.29; creatinine 1.53; 1,398-1,667; p≤0.001). Conclusion: Factors associated poisoning: ingested dose, intentional intake, sex, age. change AST, ALT, creatinine, related death. Design dynamic models variables that include their evolution during stay can optimize prediction.